Fenbendazole is an anti-parasitic drug that’s used to treat parasitic worms in animals. It also treats certain tapeworms in humans. It’s also being touted as a cancer cure by unlicensed veterinarians on TikTok and Facebook.
Scientists have found that fenbendazole could be effective in treating multiple types of cancer. The researchers believe it works through moderate microtubule disruption and p53 stabilization, and interference with glucose metabolism.
Fenbendazole is a broad-spectrum benzimidazole compound with antiparasitic activity in several species. It acts by binding to b-tubulin microtubule subunits and disrupting polymerization. It has also been shown to inhibit the growth of various cancers and have anti-tumor effects. The drug is FDA approved for use in humans, and has a track record of safety.
A new study suggests that fenbendazole, known as Pancur or Safe-Guard, may help treat a wide range of gastrointestinal diseases in humans. This includes parasitic infections such as roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris vulpis), and tapeworms (Taenia pisiformis).
The study was conducted at the National Institute of Pharmaceutical Education and Research in Chandigarh, India. The researchers used the broth microdilution method to determine the minimum inhibitory concentration (MIC) of fenbendazole. The fenbendazole solution was added to the medium in the presence of a carrier such as DMSO. The DMSO concentration was kept at 1% throughout the experiment.
The researchers found that fenbendazole was effective in reducing the number of parasites in the intestinal tracts of human volunteers. This finding is an important step in developing a new treatment for patients with gastrointestinal diseases. The study was published in the journal PLOS ONE.
In the laboratory, researchers have found that fenbendazole can slow down cancer cell growth. According to a 2021 press release from Johns Hopkins Medicine, this is due to the fact that fenbendazole, along with benzimidazole carbamates like metronidazole and albendazole, inhibits cancer cell growth by blocking the activity of certain enzymes.
In addition, fenbendazole can interfere with the formation of microtubules. These are the protein structures that give cells their shape and structure. Textbook depictions of a cell often show different organelles floating in amorphous bags of liquid, but these structures are actually assembled and disassembled by microtubules.
Another study found that fenbendazole could prevent cancer cells from absorbing glucose, which is the energy they use to grow. This research was published in the journal Scientific Reports.
A third study compared the ability of fenbendazole to kill cancer cells in the presence or absence of other anti-cancer drugs. They found that fenbendazole was more effective at killing cancer cells than amphotericin B, a commonly used chemotherapy drug.
A popular claim based on anecdotal evidence is that fenbendazole can cure cancer. While it is true that some cancer patients experience remission after taking fenbendazole, there’s no evidence that this treatment can actually cure cancer in people. Furthermore, the anecdotal cases of remission are often based on the fact that the patient also received conventional treatments at the time, which could have contributed to their remission.
Fenbendazole is a popular drug for treating parasites in animals. It is used in dogs to treat intestinal worms and other parasites, and it is also used to treat worms in horses. It is available over the counter in a variety of forms, including the wormer Panacur C.
In a laboratory setting, fenbendazole has been shown to inhibit cancer cell growth and induce cancer cell death. This is believed to be due to its effects on microtubules, which provide structure to cells and are critical in regulating cell growth. The researchers of one study found that fenbendazole could partially alter the microtubule network in human non-small cell lung cancer cells, and this reduced cancer cell proliferation and survival in vitro.
Another study, published in 2021, found that a similar drug to fenbendazole, called mebendazole, could slow tumor progression in mice with pancreatic cancer. The authors of this study suggested that fenbendazole may be able to act as a combination therapy with other conventional cancer treatments.
However, it is important to note that the studies conducted on fenbendazole were done in a laboratory setting and were not tested in human patients. A specialist cancer information nurse told Full Fact that there is insufficient evidence to suggest that fenbendazole cures cancer, and that it should only be used as part of a treatment plan that has been tested in clinical trials.
Fenbendazole is generally well tolerated by humans at doses used to treat parasites. However, the benzimidazole class can sometimes cause nausea and stomach upset. Some people may experience dizziness, headache or fatigue when taking fenbendazole.
Despite evidence from several studies that fenbendazole can reduce cancer cell growth in laboratory petri dishes and mice, it is not known whether it will work in people with actual cancers. There is also no proof that fenbendazole will prevent recurrent cancer for anyone who has had cancer in the past.
Anecdotal evidence has surfaced from a cancer patient who self-administered fenbendazole for his Stage 4 lung cancer. His story has spread through social media platforms such as Twitter and TikTok, where medical information is often unproven and difficult to filter.
Joe Tippens’ case is based on anecdotal evidence that he was able to achieve remission of his advanced non-small-cell lung cancer by taking fenbendazole. His case is unique, and there are many other factors that could have contributed to his remission. He was also receiving conventional cancer treatments at the time, which may have helped his condition more than fenbendazole alone.
Research suggests that fenbendazole might be able to target multiple pathways in the cell that regulate tumor development and growth. It can also impair the activity of p53, an important tumor suppressor gene. Consequently, it is thought that fenbendazole might help prevent the occurrence of drug resistance in patients who are treated with single-target cancer fenbendazole for humans