Fenbendazole (commonly known as fenben) is a commonly used anthelmintic drug that kills parasites and worms in animals, including roundworms, hookworms, whipworms, and tapeworms. It is also being used by some cancer patients in a treatment method called the Joe Tippens Protocol.
However, there is no evidence that fenbendazole is a cancer cure and it hasn’t been tested in human clinical trials. It isn’t approved by the U.S. Food and Drug Administration to treat cancer, and it’s not recommended as a first-line therapy for cancer patients.
In animal experiments, fenbendazole inhibits cell cycle progression by blocking microtubule-associated tubulin polymerization. This causes cyclin B1 to become unbound and degraded by the anaphase-promoting complex, which results in mitotic catastrophe and cell death. In one study, fenbendazole was shown to inhibit the proliferation of human lung adenocarcinoma cells with a KRAS mutation.
While some anecdotal accounts of a patient experiencing remission after taking fenbendazole have gone viral on social media, these stories aren’t peer-reviewed and can’t be relied upon to determine whether fenbendazole is effective against cancer. What’s often ignored is the fact that these patients were concurrently undergoing conventional cancer treatments when they reported their success, which makes it impossible to reliably attribute their remission to fenbendazole alone.
Another important point to consider is that fenbendazole has been shown to enhance the effectiveness of chemotherapy and radiation in some experimental cancer models, but it’s unlikely that this would occur in humans because of different biological mechanisms involved in tumor growth. For example, in experiments where EMT6 mammary tumor cells were irradiated and then treated with either fenbendazole, conventional cytotoxic drugs (like docetaxel or doxorubicin), or both, the addition of fenbendazole did not significantly alter the dose-response curves or increase the antineoplastic effects of the agents. fenbendazole cancer treatment